Tagata CYP2C9 ma VKORC1 Gene Polymorphism

Fa'amatalaga Puupuu:

O lenei pusa e faʻatatau i in vitro qualitative suʻesuʻega o polymorphism o CYP2C9 * 3 (rs1057910, 1075A> C) ma VKORC1 (rs9923231, -1639G> A) i le genomic DNA o tagata toto atoa samples.


Fa'amatalaga Oloa

Faailoga o oloa

Igoa o oloa

HWTS-GE014A-Tagata CYP2C9 ma VKORC1 Gene Polymorphism Detection Kit (Fluorescence PCR)

Tusi Faamaonia

CE

Epidemiology

Warfarin ose anticoagulant tautala e masani ona faʻaaogaina i falemaʻi i le taimi nei, lea e faʻamoemoe mo le puipuia ma le togafitia o faʻamaʻi thromboembolic.Ae ui i lea, o le warfarin e faʻatapulaʻa faʻamalama togafitiga ma e matua ese lava i ituaiga eseese ma tagata taʻitoʻatasi.Fa'amaumauga ua fa'ailoa mai o le eseesega o fua fa'amautu i tagata eseese e mafai ona sili atu i le 20 taimi.O le afaina o le tafe toto e tupu i le 15.2% o tagata mamaʻi o loʻo ave warfarin i tausaga taʻitasi, lea e 3.5% e maua ai le tafe toto.O suʻesuʻega a le Pharmacogenomic ua faʻaalia ai o le genetic polymorphism o le enzyme target VKORC1 ma le metabolic enzyme CYP2C9 o warfarin o se mea taua e aʻafia ai le eseesega i le fua o le warfarin.O le Warfarin o se fa'alavelave fa'apitoa ole vaitamini K epoxide reductase (VKORC1), ma fa'apea ona fa'alavelaveina le fa'atupuina o mea fa'apipi'i e aofia ai le vaitamini K ma maua ai le anticoagulation.O le tele o suʻesuʻega ua faʻaalia ai o le gene polymorphism o le VKORC1 promoter o le mea sili lea ona taua e aʻafia ai le tuuga ma le eseesega o tagata i le fua manaʻomia o warfarin.O le Warfarin e fa'afefeteina e le CYP2C9, ma o ona mutants e fa'agesegese le metabolism o le warfarin.O tagata ta'ito'atasi o lo'o fa'aaogaina warfarin e maualuga atu le lamatiaga (fa'alua i le fa'atolu taimi le maualuga) o le toto i le amataga o le fa'aoga.

Auala

FAM VKORC1 (-1639G>A)
CY5 CYP2C9*3
VIC/HEX IC

Vaega Fa'ainisinia

Teuina Suavai: ≤-18℃
Fa'asa-ola 12 masina
Ituaiga Fa'ata'ita'iga toto fou EDTA anticoagulated
CV ≤5.0%
LoD 1.0ng/μL
Fa'apitoa E leai se felafolafoaʻiga faʻatasi ma isi faʻasologa sili ona tumau o le genome tagata (tagata CYP2C19 gene, tagata RPN2 gene);suiga ole CYP2C9*13 ma le VKORC1 (3730G>A) i fafo atu o le va'aiga o lenei pusa
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Galulue Galuega

Fautuaina le fa'aaogaina o le fa'aputuga: Macro & Micro-Test Viral DNA/RNA Kit(HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) ma Macro & Micro-Test Automatic Nucleic Acid Extractor(HWTS- 3006).


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