Tagata CYP2C19 Gene Polymorphism

CYP2C19 o se tasi o vailaʻau taua e faʻaaogaina enzymes i le aiga CYP450.O le tele o mea'ai ma e tusa ma le 2% o vaila'au fa'afoma'i e fa'aogaina e le CYP2C19, e pei o le metabolism o le antiplatelet aggregation inhibitors (pei o le clopidogrel), fa'atosina pamu (omeprazole), anticonvulsants, ma isi. fualaau fa'atatau.O nei suiga o le *2 (rs4244285) ma le *3 (rs4986893) e mafua ai le leiloa o le gaioiga o le enzyme o loʻo faʻapipiʻiina e le CYP2C19 gene ma le vaivai o le gafatia o le metabolic substrate, ma faʻateleina ai le faʻaogaina o le toto, ina ia mafua ai faʻalavelave faʻaleagaina e fesoʻotaʻi ma toto maualuga.* 17 (rs12248560) e mafai ona faʻateleina le gaioiga o le enzyme e faʻapipiʻiina e le CYP2C19 gene, le gaosiga o metabolites malosi, ma faʻaleleia le faʻalavelave faʻapipiʻi platelet ma faʻateleina le lamatiaga o le toto.Mo tagata e fa'agesegese le metabolism o vaila'au, o le faia o tui masani mo se taimi umi o le a mafua ai a'afiaga ogaoga ma a'afiaga: fa'aleagaina le ate, fa'aleagaina o le hematopoietic system, fa'aleagaina o le tino, ma isi, e mafai ona o'o atu ai i le oti i tulaga ogaoga.E tusa ai ma le eseesega o tagata taʻitoʻatasi i le faʻaogaina o fualaau faʻasaina, e masani ona vaevaeina i ni faʻailoga se fa, e taʻua o le ultra-fast metabolism (UM, * 17 / * 17, * 1 / * 17), metabolism vave (RM, * 1 / * 1). ), metabolism vavalo (IM, * 1 / * 2, * 1 / * 3), metabolism lemu (PM, * 2 / * 2, * 2 / * 3, * 3 / * 3).